A disgruntled summer-stock actor contemptuously disregards the superstition surrounding Shakespeare's tragedy, Macbeth and, by doing so, unleashes the curse of 'The Scottish Play' and wreaks havoc on the company.

It's Hollywood, 1958. Small town beauty queen and devout Baptist virgin Marla Mabrey, under contract to the infamous Howard Hughes, arrives in Los Angeles. At the airport, she meets her driver Frank Forbes, who is engaged to be married to his seventh grade sweetheart and is a deeply religious Methodist. Their instant attraction not only puts their religious convictions to the test, but also defies Hughes' number one rule: No employee is allowed to have any relationship whatsoever with a contract actress. Hughes' behavior intersects with Marla and Frank in very separate and unexpected ways, and as they are drawn deeper into his bizarre world, their values are challenged and their lives are changed.

20 years after the dimwits set out on their first adventure, they head out in search of one of their long lost children in the hope of gaining a new kidney.

When she starts college in California, the US president's daughter hits some snags in her quest to live life — and fall in love — like any other girl.