All Might and Deku accept an invitation to go abroad to a floating and mobile manmade city, called 'I Island', where they research quirks as well as hero supplemental items at the special 'I Expo' convention that is currently being held on the island. During that time, suddenly, despite an iron wall of security surrounding the island, the system is breached by a villain, and the only ones able to stop him are the students of Class 1-A.

The students of class 3-E have a mission: kill their teacher before graduation. He has already destroyed the moon, and has promised to destroy the Earth if he can not be killed within a year. But how can this class of misfits kill a tentacled monster, capable of reaching Mach 20 speed, who may be the best teacher any of them have ever had?

Bell Cranell is a rookie adventurer and the sole member of his dirt-poor guild founded by the petite goddess Hestia. Adventurers come from far and wide looking to strike it big in the massive labyrinth known as Dungeon, located beneath the city of Orario. Bell is more interested in picking up girls than Dungeon-crawling, but his reality check comes sooner than expected. Saved from a brush with death by the beautiful, renowned adventurer Aiz Wallenstein, Bell falls head-over-heels and sets his sights on winning her heart, but she's not the only woman he's caught the attention of, for better of worse.

The atmosphere in True Cross Academy is lively and boisterous in the days leading up to the grand festival held once every 11 years. During this time, Okumura Rin is entrusted with the responsibility of suppressing the berserk Phantom Train. In the midst of his mission, he meets a devil whose appearance is that of a young boy.