A fast-spreading disease that turns victims into blood-sucking fiends pits two best friends against each other in a fight for humanity's future.

Extreme athlete turned government operative Xander Cage comes out of self-imposed exile, thought to be long dead, and is set on a collision course with deadly alpha warrior Xiang and his team in a race to recover a sinister and seemingly unstoppable weapon known as Pandora's Box. Recruiting an all-new group of thrill-seeking cohorts, Xander finds himself enmeshed in a deadly conspiracy that points to collusion at the highest levels of world governments.

The three sons of a Montana rancher are swept up in the violence of World War I and their love for the same woman in this epic family saga.