Boo Yong Joo was once a famous surgeon at the peak of his career at a major hospital. But he suddenly gives it all up one day to live in seclusion and work as a neighborhood doctor in a small town. He now goes by “Teacher Kim” and refers to himself as the “Romantic Doctor.” Meanwhile, Kang Dong Joo became a doctor to make something of himself after growing up poor, and he seeks out VIP patients to achieve the success that he desperately wants. Yoon Seo Jung is a passionate young surgeon who is haunted by a mistake from her past and tries to get over it. When Dong Joo and Seo Jung meet the quirky Teacher Kim, their lives and careers will never be the same again.

About the unexpected romance that occurs as Jin Moo Hak tries to steal an art museum from Kim Dal Ri. Kim Dal Ri, who was a visiting researcher at Kröller-Müller Museum and then becomes the director of Chungsong Art Museum. She is a character whose speech and actions are always classy and considerate. Dal Ri enjoys studying diverse fields such as art, philosophy, and religion, and she is proficient in seven languages. Jin Moo Hak, whose family grew a tiny gamja-tang (spicy pork back bone stew) restaurant into the global food corporation DonDon F&B. Although he is a director of the company, he is far from intelligent and was always ranked last in his class when he was in school.

Song Ah is a 29-year-old music major, but this is actually her second time in college. Despite her passion for music, the fact that she started later than her peers means she faces hurdles everywhere she goes.

Kwon Si-Hyun bets his life on a dangerous game to seduce Eun Tae-Hee. His target is 20-years-old and believes people that are swayed by love are pathetic. After Eun Tae-Hee meets Kwon Si-Hyun, her view on love changes. Based on 18th century French novel "Les Liaisons dangereuses" by Pierre Choderlos de Laclos.

Yoo Hyun-Jae is a member of a popular idol group. He has a lot of fans and he is a scandal maker. Meanwhile, Lee Ji-Hoon is an aspiring singer. He pretends to be studying for his civil servant exam, but he is actually struggling to become an idol.

In his quest for a bride to break his immortal curse, a 939-year-old guardian of souls meets a grim reaper and a sprightly student with a tragic past.

Cha Jung-Han (Oh Ji-Ho) is a detective for a special investigation team. He is busy with investigating violent cases including drugs and gangs, but one day he takes in his niece Eun-Ae and struggles to raise her.