Elizabeth Holmes, an optimistic and determined young woman, drops out of Stanford to found a promising new blood testing startup.

Physicists Leonard and Sheldon find their nerd-centric social circle with pals Howard and Raj expanding when aspiring actress Penny moves in next door.

A suave New York dating coach finds himself uncharacteristically smitten when he meets a smart, cynical reporter who seems immune to his charms.

Determined to learn about her boyfriend's past relationships, a talk show producer interviews his ex-lovers, supposedly for an upcoming show.