Thaggede Le story is about a murder investigation that revolves around nabbing of a drug lord. SI Chalapathy (Ravi Shankar) and his subordinate Raja (Raja Raveendra) bring Easwar (Naveen Chandra) , a software engineer to a Daba and start interrogating him over a murder case. Even as they are busy with their interrogation, the drug mafia is furious with the missing cartel and the dreaded Dandupalyam gang comprising gang leader Krishna (Makarand Desh Pande), Lakshmi (Pooja Gandhi), Chander (Ravi Kale), and others escape. Where this leads to and what is the connection to the murder mystery and how they are related to Eswar's wife Devi (Divya Pillai), Lizy (Ananaya SenGupta) form the crux of Thaggede Le.

3Devi is a riveting story of a leading actress, an entrepreneur and bride-to-be, and an assistant director who are fed up with male chauvinism in their respective fields. On a particularly trying day, the actress and the assistant director leave their film set in the middle of a shoot, while the bride leaves her groom at the church altar. The three women band together to take a relaxing hiatus away from their problems. But a sudden turn of events forces them into a battle for their lives.

Upon prosecution, when a gang gets arrested and sentenced to death for eighty murders, a journalist takes it on herself to investigate the case.