Two years after the events of the Fourth Great Ninja War, the moon that Hagoromo Otsutsuki created long ago to seal away the Gedo Statue begins to descend towards the world, threatening to become a meteor that would destroy everything on impact. Amidst this crisis, a direct descendant of Kaguya Otsutsuki named Toneri Otsutsuki attempts to kidnap Hinata Hyuga but ends up abducting her younger sister Hanabi. Naruto and his allies now mount a rescue mission before finding themselves embroiled in a final battle to decide the fate of everything.

After his capture for attempted assassination of the Raikage, leader of Kumogakure, as well as killing J?nin from Kirigakure and Iwagakure, Naruto is imprisoned in H?zukijou: A criminal containment facility known as the Blood Prison. Mui, the castle master, uses the ultimate imprisonment technique to steal power from the prisoners, which is when Naruto notices his life has been targeted. Thus begins the battle to uncover the truth behind the mysterious murders and prove Naruto's innocence.

Naruto Uzumaki, Kakashi Hatake, Sakura Haruno, and Rock Lee are assigned to protect the prince of the Land of the Moon, Michiru, during his world trip; other escorts had been hired, but quit due to being treated poorly. The Land of the Moon is a very wealthy nation, so Michiru tends to buy whatever he wants, and has a very materialistic worldview. His Hikaru, also acts in much the same manner.

Jaga Bada, Mr. Satan's old sparring partner, has invited Satan to his personal island to hold a grudge match. Trunks and Goten decide to come for the adventure and Android #18 is following Satan for the money he owes her. Little do they know that Jaga Bada's scientist have found a way to resurrect Broly, the legendary Super Saiyan.

Sakuragi Hanamichi is a junior high punk used to getting into fights and being rejected by girls but upon entering high school he meets the girl of his dreams, Haruko Akagi. He will do anything in order to win her heart including joining the school basketball team that is aiming to conquer the nation lead by Haruko's brother. The problem is that Sakuragi has never played basketball before and a freshman sensation is stealing the spotlight and Haruko's affection from him.

Mr. Money is holding another World Martial Arts Tournament and Mr. Satan invites everyone in the world to join in. Little does he know that Bojack, an ancient villain who has escaped his prison, is competing. Since Goku is currently dead, it is up to Gohan, Vegeta, and Trunks to defeat Bojack and his henchman.

Dr. Gero's Androids #13, #14, and #15 are awakened by the laboratory computers and immediately head to the mall where Goku is shopping. After Goku, Trunks, and Vegeta defeat #14 and #15, #13 absorbs their inner computers and becomes a super being greater than the original three separately were. Now it is up to Goku to stop him.

Cooler has resurrected himself as a robot and is enslaving the people of New Namek. Goku and the gang must help.