A small West Virginia town is hosting the legendary Mountain Man Festival on Halloween, where throngs of costumed party goers gather for a wild night of music and mischief. But an inbred family of hillbilly cannibals kill the fun when they trick and treat themselves to a group of visiting college students.

Duff Daniels steals a rare snake from a Native American dealer. The situation becomes worse when the snake goes on a killing spree, eating humans and animals alike.