When a shadowy CIA agent uncovers damning agency secrets, he’s hunted across the globe by a sociopathic rogue operative who’s put a bounty on his head.

A few decades from now - Sienna, a rebellious robot-fighting arms dealer, lives on a post-apocalyptic Earth. When the cities start to fall under the control of the A.I. Scourge, a hyper-weaponized robot army, Sienna decides to leave the Earth and journey to the centre of the galaxy, seeking a mythical weapon that can neutralize any form of A.I.Pursued by giant machines, Sienna loses everything she cares about in an effort to save the last vestiges of humanity in an A.I. controlled galaxy.

A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires.