A strange black entity from another world bonds with Peter Parker and causes inner turmoil as he contends with new villains, temptations, and revenge.

Peter Parker is beset with troubles in his failing personal life as he battles a former brilliant scientist named Otto Octavius.

After being bitten by a genetically-modified spider, a shy teenager gains spider-like abilities that he uses to fight injustice as a masked superhero and face a vengeful enemy.