Shaun Murphy, a young surgeon with autism and Savant syndrome, is recruited into the surgical unit of a prestigious hospital.

Astronaut Molly Woods tries to reconnect with her husband, John, and son, Ethan, after returning from a 13-month solo mission in outer space. Her experiences can change the course of human history.

After their plane crashes into the Amazon River, each member of the Powell family starts to show signs of new, unique and distinct super powers.