After witnessing disease and poverty in the slums of New York, Italian immigrant Francesca Cabrini embarks on a daring journey to persuade the hostile mayor to provide housing and healthcare for hundreds of orphaned children.

Dr. Dylan Reinhart, a gifted author, university professor and former CIA operative is lured back to his old life by tenacious top NYPD Detective Lizzie Needham. Though Dylan and Lizzie initially clash, when it comes to catching killers, they make an ideal team.

Two fathers with clashing views about their children's upcoming wedding struggle to keep it together during the chaotic week before the big day.