Picking up immediately after the events in Resident Evil: Retribution, Alice (Milla Jovovich) is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.

In search of a rumored safe haven, Alice takes refuge with a group of survivors in a Los Angeles prison surrounded by hordes of undead.

A successful executive with the perfect job and perfect wife finds his life falling apart when a sexy office temp sets out to seduce and destroy him.

Kimberly has a premonition of an accident killing multiple people including her and her friends. She blocks the cars behind her on the ramp and as a police trooper arrives, the accident happens. Death is stalking this group of survivors.

Alex Browning is among a group of high school students on a trip to Europe. He suddenly has a premonition their airplane will crash, he screams to warn the others but is thrown off of the plane, and the plane crashes after they get off.