After an unjust 16-year prison sentence, Dolores Roach returns to a gentrified Washington Heights, where she reunites with an old stoner friend, Luis, who lets her live and work as a masseuse in the basement under his empanada shop. When the promise of her newfound stability is quickly threatened, “Magic Hands” Dolores is driven to shocking extremes to survive.

As part of a racist government policy now known as the Sixties Scoop, Bezhig Little Bird is removed from her home in Long Pine Reserve in Saskatchewan and adopted into a Montréal Jewish family at the age of five, becoming Esther Rosenblum. Now in her 20s, Bezhig longs for the family she lost and is willing to sacrifice everything to find them.

A young woman with enhanced abilities finds herself hunted down by a sinister government organization. But when an even stronger enhanced serial killer emerges on the scene, agents and mutants are forced to question their allegiances.